Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1552)
DME Name Cytochrome P450 142A1 (cyp142), Mycobacterium tuberculosis DME Info
UniProt ID
CP142_MYCTU
EC Number    EC: 1.14.15.28     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.28
Lineage    Species: Mycobacterium tuberculosis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: Mycobacterium tuberculosis
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: ANW-32821 Click to Show/Hide the Full List of HOSPPI:        4 HOSPPI
                            Cholesterol 24-hydroxylase (CYP46A1) Click to Show/Hide the Cometabolization Info
DME ID DME0028 DME Info
Uniprot ID
CP46A_HUMAN
Interaction Name CYP46A1-cyp142 interaction [1], [2]
Description The interaction, between human Cholesterol 24-hydroxylase and Cytochrome P450 142A1 from Mycobacterium tuberculosis which collectively metabolize the drug ANW-32821, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cholesterol desmolase (CYP11A1) Click to Show/Hide the Cometabolization Info
DME ID DME0099 DME Info
Uniprot ID
CP11A_HUMAN
Interaction Name CYP11A1-cyp142 interaction [1], [2]
Description The interaction, between human Cholesterol desmolase and Cytochrome P450 142A1 from Mycobacterium tuberculosis which collectively metabolize the drug ANW-32821, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 7A1 (CYP7A1) Click to Show/Hide the Cometabolization Info
DME ID DME0624 DME Info
Uniprot ID
CP7A1_HUMAN
Interaction Name CYP7A1-cyp142 interaction [1], [2]
Description The interaction, between human Cytochrome P450 7A1 and Cytochrome P450 142A1 from Mycobacterium tuberculosis which collectively metabolize the drug ANW-32821, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Vitamin D(3) 25-hydroxylase (CYP27A1) Click to Show/Hide the Cometabolization Info
DME ID DME0026 DME Info
Uniprot ID
CP27A_HUMAN
Interaction Name CYP27A1-cyp142 interaction [1], [2]
Description The interaction, between human Vitamin D(3 25-hydroxylase and Cytochrome P450 142A1 from Mycobacterium tuberculosis which collectively metabolize the drug ANW-32821, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614.
2 Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos. 2006 Apr;34(4):513-20.

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