Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1615)
DME Name Naphthalene dioxygenase (doxB), Pseudomonas furukawaii DME Info
UniProt ID
NDOB_PSEU8
EC Number    EC: 1.14.12.12     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
NADH/NADPH donor oxidoreductase
EC: 1.14.12.12
Lineage    Species: Pseudomonas furukawaii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Pseudomonadaceae
Genus: Pseudomonas
Species: Pseudomonas furukawaii
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Flavone Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 2A6 (CYP2A6) Click to Show/Hide the Cometabolization Info
DME ID DME0005 DME Info
Uniprot ID
CP2A6_HUMAN
Interaction Name CYP2A6-doxB interaction [1], [2]
Description The interaction, between human Cytochrome P450 2A6 and Naphthalene dioxygenase from Pseudomonas furukawaii which collectively metabolize the drug Flavone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. Appl Microbiol Biotechnol. 2011 Jul;91(2):219-28.
2 Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes. Xenobiotica. 2019 Jul;49(7):791-802.

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