Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1630)
DME Name	VanA ligase (vanA), Enterococcus gallinarum	DME Info
UniProt ID	A0A376GZ73_ENTGA
EC Number	EC: 6.3.2.4 (Click to Show/Hide the Complete EC Tree) Ligase Carbon-nitrogen ligase Peptide synthase EC: 6.3.2.4
Lineage	Species: Enterococcus gallinarum (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Enterococcaceae Genus: Enterococcus Species: Enterococcus gallinarum Subspecies: Enterococcus gallinarum BM4231
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
Drug co-metabolism
Cometabolized drug: Teicoplanin		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Sulfotransferase 1A1 (SULT1A1)		Click to Show/Hide the Cometabolization Info
DME ID	DME0008 DME Info
Uniprot ID	ST1A1_HUMAN
Interaction Name	SULT1A1-vanA interaction		[1], [2]
Description	The interaction, between human Sulfotransferase 1A1 and VanA ligase from Enterococcus gallinarum which collectively metabolize the drug Teicoplanin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.

References
1	Emergence of high-level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliflavus. Antimicrob Agents Chemother. 1994 Jul;38(7):1675-7.
2	The 2.7 A resolution structure of the glycopeptide sulfotransferase Teg14. Acta Crystallogr D Biol Crystallogr. 2010 Dec;66(Pt 12):1278-86.

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