Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1949)
DME Name Arginine dihydrolase (arcA), Staphylococcus petrasii DME Info
UniProt ID
A0A380FWY5_9STAP
EC Number    EC: 3.5.3.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Linear amidine hydrolase
EC: 3.5.3.6
Lineage    Species: Staphylococcus petrasii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Staphylococcaceae
Genus: Staphylococcus
Species: Staphylococcus petrasii
Subspecies: Staphylococcus petrasii subsp. Jettensis
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: L-arginine Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Liver-type arginase (ARG1) Click to Show/Hide the Cometabolization Info
DME ID DME0489 DME Info
Uniprot ID
ARGI1_HUMAN
Interaction Name ARG1-arcA interaction [1], [2]
Description The interaction, between human Liver-type arginase and Arginine dihydrolase from Staphylococcus petrasii which collectively metabolize the drug L-arginine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Staphylococcus jettensis sp. nov., a coagulase-negative staphylococcal species isolated from human clinical specimens. Int J Syst Evol Microbiol. 2013 Sep;63(Pt 9):3250-6.
2 Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13058-63.

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