Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1957)
DME Name Methylenetetrahydrofolate reductase (metF), Streptococcus sanguinis DME Info
UniProt ID
A3CL12_STRSV
EC Number    EC: 1.5.1.20     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.20
Lineage    Species: Streptococcus sanguinis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus sanguinis
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: ISO-901 Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Methylenetetrahydrofolate reductase (MTHFR) Click to Show/Hide the Cometabolization Info
DME ID DME0083 DME Info
Uniprot ID
MTHR_HUMAN
Interaction Name MTHFR-metF interaction [1], [2]
Description The interaction, between human Methylenetetrahydrofolate reductase and Methylenetetrahydrofolate reductase from Streptococcus sanguinis which collectively metabolize the drug ISO-901, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Functional profiles of coronal and dentin caries in children. J Oral Microbiol. 2018 Jul 16;10(1):1495976.
2 Methylenetetrahydrofolate reductase gene polymorphisms: genomic predictors of clinical response to fluoropyrimidine-based chemotherapy? Cancer Chemother Pharmacol. 2006 Jun;57(6):835-40.

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