Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME2014)
DME Name Insulin-degrading enzyme (ide), Vibrio vulnificus DME Info
UniProt ID
A0A0C1JXV9_9BACT
EC Number    EC: 3.4.24.56     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Metallopeptidase
EC: 3.4.24.56
Lineage    Species: Vibrio vulnificus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: Vibrio vulnificus
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Insulin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Insulin-degrading enzyme (IDE) Click to Show/Hide the Cometabolization Info
DME ID DME0494 DME Info
Uniprot ID
IDE_HUMAN
Interaction Name IDE-ide interaction [1], [2], [3]
Description The interaction, between human Insulin-degrading enzyme and Insulin-degrading enzyme from Vibrio vulnificus which collectively metabolize the drug Insulin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Vibrio vulnificus secretes an insulin-degrading enzyme that promotes bacterial proliferation in vivo. J Biol Chem. 2015 Jul 24;290(30):18708-20.
2 Complete genome sequence of Vibrio vulnificus FORC_017 isolated from a patient with a hemorrhagic rash after consuming raw dotted gizzard shad. Gut Pathog. 2016 Jun 20;8:22.
3 Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. Biochemistry. 2005 May 3;44(17):6513-25.

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