Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0007)
DME Name RNA cytidine acetyltransferase (hALP), Homo sapiens DME Info
UniProt ID
NAT10_HUMAN
EC Number    EC: 2.3.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Chlamydiae
                  Chlamydia muridarum (chlamydias) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human RNA cytidine acetyltransferase (hALP) and Chlamydia muridarum co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2], [3]
      Bacteria: Firmicutes
                  Lactobacillus casei (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human RNA cytidine acetyltransferase (hALP) and Lactobacillus casei co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4], [5]
      Bacteria: Proteobacteria
                  Acinetobacter baumannii (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Netilmicin Click to Show/Hide the Detail
                                 Drug ID DR1139   Drug Info
                                 Interaction Mechanism Human RNA cytidine acetyltransferase (hALP) and Acinetobacter baumannii co-metabolize the drug Netilmicin, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [7]
                              Tobramycin Click to Show/Hide the Detail
                                 Drug ID DR1606   Drug Info
                                 Interaction Mechanism Human RNA cytidine acetyltransferase (hALP) and Acinetobacter baumannii co-metabolize the drug Tobramycin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [7]
                  Campylobacter coli (epsilon-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Tobramycin Click to Show/Hide the Detail
                                 Drug ID DR1606   Drug Info
                                 Interaction Mechanism Human RNA cytidine acetyltransferase (hALP) and Campylobacter coli co-metabolize the drug Tobramycin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [9]
                  Campylobacter jejuni (epsilon-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Tobramycin Click to Show/Hide the Detail
                                 Drug ID DR1606   Drug Info
                                 Interaction Mechanism Human RNA cytidine acetyltransferase (hALP) and Campylobacter jejuni co-metabolize the drug Tobramycin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [9]
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Clonazepam Click to Show/Hide the Detail
                                 Drug ID DR0351   Drug Info
                                 Interaction Mechanism Human RNA cytidine acetyltransferase (hALP) and Escherichia coli co-metabolize the drug Clonazepam, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [11]
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human RNA cytidine acetyltransferase (hALP) and Escherichia coli co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [12], [13]
                  Shewanella oneidensis (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Sulfamethoxazole Click to Show/Hide the Detail
                                 Drug ID DR1511   Drug Info
                                 Interaction Mechanism Human RNA cytidine acetyltransferase (hALP) and Shewanella oneidensis co-metabolize the drug Sulfamethoxazole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [15], [16]
                              Sulfapyridine Click to Show/Hide the Detail
                                 Drug ID DR1512   Drug Info
                                 Interaction Mechanism Human RNA cytidine acetyltransferase (hALP) and Shewanella oneidensis co-metabolize the drug Sulfapyridine, which can collectively affect efficacy, safety or bioavailability of this drug. [17], [15], [16]
      Bacteria: Synergistetes
                  Synergistetes bacterium (synergistetes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Sulfamethoxazole Click to Show/Hide the Detail
                                 Drug ID DR1511   Drug Info
                                 Interaction Mechanism Human RNA cytidine acetyltransferase (hALP) and Synergistetes bacterium co-metabolize the drug Sulfamethoxazole, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [18], [19]
References
1 Arylamine N-acetyltransferase in human red blood cells. Biochem Pharmacol. 1992 Sep 25;44(6):1099-104.
2 Biophysical principles predict fitness landscapes of drug resistance. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1470-8.
3 The Genital tract virulence factor pGP3 is essential for Chlamydia muridarum colonization in the gastrointestinal tract. Infect Immun. 2017 Dec 19;86(1). pii: e00429-17.
4 Molecular cloning of the gene for dihydrofolate reductase from Lactobacillus casei. Gene. 1982 Feb;17(2):229-33.
5 Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site. Biochemistry. 2008 Feb 26;47(8):2388-96.
6 Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase. Antimicrob Agents Chemother. 2003 May;47(5):1577-83.
7 Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5.
8 Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6'-N-acetyltransferase Ib and IIa proteins. J Bacteriol. 1992 May;174(10):3196-203.
9 Cloning and expression of novel aminoglycoside phosphotransferase genes from Campylobacter and their role in the resistance to six aminoglycosides. Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01682-17.
10 Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam. Drug Metab Lett. 2007 Jan;1(1):3-5.
11 Characterization of Escherichia coli nitroreductase NfsB in the metabolism of nitrobenzodiazepines. Biochem Pharmacol. 2009 Jul 1;78(1):96-103.
12 Measurement of the uptake of radioactive para-aminobenzoic acid monitors folate biosynthesis in Escherichia coli K-12. Anal Biochem. 1994 Feb 1;216(2):427-30.
13 The influence of CsgD on the expression of genes of folate metabolism and hmp in Escherichia coli K-12. Arch Microbiol. 2013 Aug;195(8):559-69.
14 Crystallization and preliminary X-ray characterization of arylamine N-acetyltransferase C (BanatC) from Bacillus anthracis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt 10):862-4.
15 Biodegradation of sulfonamides by Shewanella oneidensis MR-1 and Shewanella sp. strain MR-4. Biodegradation. 2018 Apr;29(2):129-140.
16 The 285 kDa Bap/RTX hybrid cell surface protein (SO4317) of Shewanella oneidensis MR-1 is a key mediator of biofilm formation. Res Microbiol. 2010 Mar;161(2):144-52.
17 Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population. Clin Chim Acta. 2009 Sep;407(1-2):30-5.
18 Bacterial community changes and antibiotic resistance gene quantification in microbial electrolysis cells during long-term sulfamethoxazole treatment. Bioresour Technol. 2019 Dec;294:122170.
19 Distributions of Synergistetes in clinically-healthy and diseased periodontal and peri-implant niches. Microb Pathog. 2016 May;94:90-103.

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