Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0017)
DME Name Cytochrome P450 2C18 (CYP2C18), Homo sapiens DME Info
UniProt ID
CP2CI_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium adolescentis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bifidobacterium adolescentis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium breve (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bifidobacterium breve co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium longum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bifidobacterium longum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium ruminatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bifidobacterium ruminatum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Collinsella intestinalis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Collinsella intestinalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Eggerthella lenta (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Eggerthella lenta co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Streptomyces avermitilis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Streptomyces avermitilis co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4], [5]
      Bacteria: Bacteroidetes
                  Alistipes indistinctus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Alistipes indistinctus co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Alistipes indistinctus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides cellulosilyticus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides cellulosilyticus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides coprophilus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides coprophilus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) metabolizes the drug Diclofenac sodium, and Bacteroides dorei further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [7]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides dorei co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides dorei co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Bacteroides eggerthii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides eggerthii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides finegoldii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides finegoldii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides fragilis co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides fragilis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Warfarin sodium Click to Show/Hide the Detail
                                 Drug ID DR1717   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides fragilis co-metabolize the drug Warfarin sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Bacteroides intestinalis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides intestinalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides oleiciplenus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides oleiciplenus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [10]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides ovatus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides sartorii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides sartorii co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides stercoris co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides thetaiotaomicron co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides uniformis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides uniformis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides vulgatus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides vulgatus co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Verapamil hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1681   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides vulgatus co-metabolize the drug Verapamil hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Warfarin sodium Click to Show/Hide the Detail
                                 Drug ID DR1717   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides vulgatus co-metabolize the drug Warfarin sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides xylanisolvens co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides xylanisolvens co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Odoribacter splanchnicus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Phenytoin Click to Show/Hide the Detail
                                 Drug ID DR1282   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Parabacteroides distasonis co-metabolize the drug Phenytoin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                  Parabacteroides johnsonii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Parabacteroides johnsonii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides merdae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Parabacteroides merdae co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Prevotella copri co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Anaerobutyricum hallii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Anaerococcus hydrogenalis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Anaerococcus hydrogenalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Anaerostipes hadrus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Anaerostipes hadrus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Anaerotruncus colihominis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Anaerotruncus colihominis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacillus megaterium co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [11]
                  Bacteroides pectinophilus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Bacteroides pectinophilus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Blautia hansenii co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Blautia hansenii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Blautia luti (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Blautia luti co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridioides difficile (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Clostridioides difficile co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Clostridium botulinum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium scindens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Clostridium scindens co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium spiroforme (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Clostridium spiroforme co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium sporogenes (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Clostridium sporogenes co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium symbiosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Clostridium symbiosum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Coprococcus comes (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Coprococcus comes co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Dorea formicigenerans (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Dorea formicigenerans co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterocloster asparagiformis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Enterocloster asparagiformis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterocloster bolteae (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Enterocloster bolteae co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterococcus faecalis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Enterococcus faecalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Erysipelatoclostridium ramosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Erysipelatoclostridium ramosum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Eubacterium rectale (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Eubacterium rectale co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Eubacterium ventriosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Eubacterium ventriosum co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Faecalibacterium prausnitzii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) metabolizes the drug Diclofenac sodium, and Faecalibacterium prausnitzii further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [7]
                  Holdemanella biformis (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Cyclophosphamide Click to Show/Hide the Detail
                                 Drug ID DR0391   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Holdemanella biformis co-metabolize the drug Cyclophosphamide, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Holdemanella biformis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Hungatella hathewayi (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Hungatella hathewayi co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Lactobacillus reuteri (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Lactobacillus reuteri co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Lactobacillus rhamnosus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) metabolizes the drug Diclofenac sodium, and Lactobacillus rhamnosus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [7]
                  Marvinbryantia formatexigens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Marvinbryantia formatexigens co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Roseburia intestinalis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Roseburia intestinalis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Ruminococcus gnavus (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) metabolizes the drug Diclofenac sodium, and Ruminococcus gnavus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [7]
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Ruminococcus gnavus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Ruminococcus lactaris (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Ruminococcus lactaris co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Ruminococcus torques (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Ruminococcus torques co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Subdoligranulum variabile (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Subdoligranulum variabile co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Lentisphaerae
                  Victivallis vadensis (PVC bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Victivallis vadensis co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Edwardsiella tarda (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Edwardsiella tarda co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterobacter cancerogenus (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Enterobacter cancerogenus co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Escherichia coli co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Proteus penneri (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Proteus penneri co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Providencia alcalifaciens (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Providencia alcalifaciens co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Providencia rettgeri (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Providencia rettgeri co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Providencia stuartii (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Providencia stuartii co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Salmonella enterica co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Verrucomicrobia
                  Akkermansia muciniphila (verrucomicrobiae) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omeprazole Click to Show/Hide the Detail
                                 Drug ID DR1196   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 2C18 (CYP2C18) and Akkermansia muciniphila co-metabolize the drug Omeprazole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes. Drug Metab Dispos. 1996 Oct;24(10):1081-7.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70.
4 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
5 Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from Streptomyces avermitilis. J Microbiol Biotechnol. 2017 May 28;27(5):956-964.
6 Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66.
7 tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.
8 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
9 Human P450 metabolism of warfarin. Pharmacol Ther. 1997;73(1):67-74.
10 Metabolism of omeprazole by gut flora in rats. J Pharm Sci. 1995 Apr;84(4):516-7. Letter
11 Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753.

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