Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0039)
DME Name Dimethylaniline oxidase 3 (FMO3), Homo sapiens DME Info
UniProt ID
FMO3_HUMAN
EC Number    EC: 1.14.13.8     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
NADH/NADPH donor oxidoreductase
EC: 1.14.13.8
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium ruminatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dasatinib Click to Show/Hide the Detail
                                 Drug ID DR0423   Drug Info
                                 Interaction Mechanism Human Dimethylaniline oxidase 3 (FMO3) and Bifidobacterium ruminatum co-metabolize the drug Dasatinib, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Bacteroidetes
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dasatinib Click to Show/Hide the Detail
                                 Drug ID DR0423   Drug Info
                                 Interaction Mechanism Human Dimethylaniline oxidase 3 (FMO3) and Bacteroides fragilis co-metabolize the drug Dasatinib, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dasatinib Click to Show/Hide the Detail
                                 Drug ID DR0423   Drug Info
                                 Interaction Mechanism Human Dimethylaniline oxidase 3 (FMO3) and Blautia hansenii co-metabolize the drug Dasatinib, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dasatinib Click to Show/Hide the Detail
                                 Drug ID DR0423   Drug Info
                                 Interaction Mechanism Human Dimethylaniline oxidase 3 (FMO3) and Clostridium botulinum co-metabolize the drug Dasatinib, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterocloster bolteae (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dasatinib Click to Show/Hide the Detail
                                 Drug ID DR0423   Drug Info
                                 Interaction Mechanism Human Dimethylaniline oxidase 3 (FMO3) and Enterocloster bolteae co-metabolize the drug Dasatinib, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Lactobacillus reuteri (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dasatinib Click to Show/Hide the Detail
                                 Drug ID DR0423   Drug Info
                                 Interaction Mechanism Human Dimethylaniline oxidase 3 (FMO3) and Lactobacillus reuteri co-metabolize the drug Dasatinib, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

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