Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0044)
DME Name Monoamine oxidase type A (MAO-A), Homo sapiens DME Info
UniProt ID
AOFA_HUMAN
EC Number    EC: 1.4.3.4     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH2 donor oxidoreductase
Oxygen acceptor oxidoreductase
EC: 1.4.3.4
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Bacteroidetes
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Sumatriptan succinate Click to Show/Hide the Detail
                                 Drug ID DR1517   Drug Info
                                 Interaction Mechanism Human Monoamine oxidase type A (MAO-A) and Bacteroides fragilis co-metabolize the drug Sumatriptan succinate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Sumatriptan succinate Click to Show/Hide the Detail
                                 Drug ID DR1517   Drug Info
                                 Interaction Mechanism Human Monoamine oxidase type A (MAO-A) and Bacteroides thetaiotaomicron co-metabolize the drug Sumatriptan succinate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Odoribacter laneus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Epinephrine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0590   Drug Info
                                 Interaction Mechanism Human Monoamine oxidase type A (MAO-A) and Odoribacter laneus co-metabolize the drug Epinephrine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
References
1 Subcutaneous sumatriptan pharmacokinetics: delimiting the monoamine oxidase inhibitor effect. Headache. 2010 Feb;50(2):249-55.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study. J Neurooncol. 2019 Nov;145(2):287-294.
4 Alistipes indistinctus sp. nov. and Odoribacter laneus sp. nov., common members of the human intestinal microbiota isolated from faeces. Int J Syst Evol Microbiol. 2010 Jun;60(Pt 6):1296-302.

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