Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0045)
DME Name Monoamine oxidase type B (MAO-B), Homo sapiens DME Info
UniProt ID
AOFB_HUMAN
EC Number    EC: 1.4.3.4     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH2 donor oxidoreductase
Oxygen acceptor oxidoreductase
EC: 1.4.3.4
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Eggerthella lenta (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dopamine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0532   Drug Info
                                 Interaction Mechanism Human Monoamine oxidase type B (MAO-B) and Eggerthella lenta co-metabolize the drug Dopamine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury. Biochim Biophys Acta. 2011 Jul;1813(7):1323-32.
2 Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science. 2019 Jun 14;364(6445). pii: eaau6323.

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