Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0049)
DME Name UDP-glucuronosyltransferase 2B15 (UGT2B15), Homo sapiens DME Info
UniProt ID
UDB15_HUMAN
EC Number    EC: 2.4.1.17     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.17
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Bacteroidetes
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B15 (UGT2B15) and Bacteroides fragilis co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B15 (UGT2B15) and Bacteroides sartorii co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B15 (UGT2B15) and Bacteroides stercoris co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B15 (UGT2B15) and Bacteroides thetaiotaomicron co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B15 (UGT2B15) and Bacteroides xylanisolvens co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B15 (UGT2B15) and Odoribacter splanchnicus co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B15 (UGT2B15) and Bacillus megaterium co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Clostridioides difficile (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B15 (UGT2B15) and Clostridioides difficile co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [5]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B15 (UGT2B15) and Clostridium botulinum co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium sporogenes (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B15 (UGT2B15) and Clostridium sporogenes co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterococcus faecalis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B15 (UGT2B15) and Enterococcus faecalis co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [5]
      Bacteria: Proteobacteria
                  Citrobacter freundii (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B15 (UGT2B15) and Citrobacter freundii co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [5]
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B15 (UGT2B15) and Escherichia coli co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [5]
      Fungi: Ascomycota
                  Saccharomyces cerevisiae (ascomycota) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B15 (UGT2B15) metabolizes the drug Acetaminophen, and Saccharomyces cerevisiae further metabolizes its metabolite (1-Phenyl-1,2-propanedione), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [5]
References
1 Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Characterization of niflumic acid as a selective inhibitor of human liver microsomal UDP-glucuronosyltransferase 1A9: application to the reaction phenotyping of acetaminophen glucuronidation. Drug Metab Dispos. 2011 Apr;39(4):644-52.
4 The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.
5 Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018 Jul;69(1):51-59.

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