Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0051)
DME Name N-acetyltransferase 2 (NAT2), Homo sapiens DME Info
UniProt ID
ARY2_HUMAN
EC Number    EC: 2.3.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Bacteroidetes
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Aspirin Click to Show/Hide the Detail
                                 Drug ID DR1749   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Prevotella copri co-metabolize the drug Aspirin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Jeotgalicoccus psychrophilus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Aspirin Click to Show/Hide the Detail
                                 Drug ID DR1749   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Jeotgalicoccus psychrophilus co-metabolize the drug Aspirin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Ruminococcus albus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Aspirin Click to Show/Hide the Detail
                                 Drug ID DR1749   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Ruminococcus albus co-metabolize the drug Aspirin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Citrobacter amalonaticus (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Asacolitin Click to Show/Hide the Detail
                                 Drug ID DR1967   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Citrobacter amalonaticus co-metabolize the drug Asacolitin, which can collectively affect efficacy, safety or bioavailability of this drug. [3]
                  Citrobacter farmeri (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Asacolitin Click to Show/Hide the Detail
                                 Drug ID DR1967   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Citrobacter farmeri co-metabolize the drug Asacolitin, which can collectively affect efficacy, safety or bioavailability of this drug. [3]
                  Citrobacter freundii (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Asacolitin Click to Show/Hide the Detail
                                 Drug ID DR1967   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Citrobacter freundii co-metabolize the drug Asacolitin, which can collectively affect efficacy, safety or bioavailability of this drug. [3]
                  Helicobacter apodemus (epsilon-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Aspirin Click to Show/Hide the Detail
                                 Drug ID DR1749   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Helicobacter apodemus co-metabolize the drug Aspirin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Klebsiella oxytoca (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Asacolitin Click to Show/Hide the Detail
                                 Drug ID DR1967   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Klebsiella oxytoca co-metabolize the drug Asacolitin, which can collectively affect efficacy, safety or bioavailability of this drug. [3]
                  Klebsiella pneumoniae (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Asacolitin Click to Show/Hide the Detail
                                 Drug ID DR1967   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Klebsiella pneumoniae co-metabolize the drug Asacolitin, which can collectively affect efficacy, safety or bioavailability of this drug. [3]
                  Morganella morganii (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Asacolitin Click to Show/Hide the Detail
                                 Drug ID DR1967   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Morganella morganii co-metabolize the drug Asacolitin, which can collectively affect efficacy, safety or bioavailability of this drug. [3]
                  Plesiomonas shigelloides (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Asacolitin Click to Show/Hide the Detail
                                 Drug ID DR1967   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Plesiomonas shigelloides co-metabolize the drug Asacolitin, which can collectively affect efficacy, safety or bioavailability of this drug. [3]
                  Pseudomonas aeruginosa (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Asacolitin Click to Show/Hide the Detail
                                 Drug ID DR1967   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Pseudomonas aeruginosa co-metabolize the drug Asacolitin, which can collectively affect efficacy, safety or bioavailability of this drug. [3]
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Asacolitin Click to Show/Hide the Detail
                                 Drug ID DR1967   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Salmonella enterica co-metabolize the drug Asacolitin, which can collectively affect efficacy, safety or bioavailability of this drug. [3]
                  Serratia marcescens (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Asacolitin Click to Show/Hide the Detail
                                 Drug ID DR1967   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Serratia marcescens co-metabolize the drug Asacolitin, which can collectively affect efficacy, safety or bioavailability of this drug. [3]
                  Shigella flexneri (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Asacolitin Click to Show/Hide the Detail
                                 Drug ID DR1967   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Shigella flexneri co-metabolize the drug Asacolitin, which can collectively affect efficacy, safety or bioavailability of this drug. [3]
                  Vibrio cholerae (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Asacolitin Click to Show/Hide the Detail
                                 Drug ID DR1967   Drug Info
                                 Interaction Mechanism Human N-acetyltransferase 2 (NAT2) and Vibrio cholerae co-metabolize the drug Asacolitin, which can collectively affect efficacy, safety or bioavailability of this drug. [3]
References
1 Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. Allergy Asthma Immunol Res. 2011 Oct;3(4):273-6.
2 Gut microbiota-mediated drug-drug interaction between amoxicillin and aspirin. Sci Rep. 2019 Nov 7;9(1):16194.
3 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.

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