Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0056)
DME Name Carboxylesterase 3 (CES3), Homo sapiens DME Info
UniProt ID
EST3_HUMAN
EC Number    EC: 3.1.1.1     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Bacteroidetes
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 3 (CES3) metabolizes the drug Irinotecan hydrochloride, and Bacteroides thetaiotaomicron further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides uniformis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 3 (CES3) metabolizes the drug Irinotecan hydrochloride, and Bacteroides uniformis further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Clostridium perfringens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 3 (CES3) metabolizes the drug Irinotecan hydrochloride, and Clostridium perfringens further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Streptococcus agalactiae (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 3 (CES3) metabolizes the drug Irinotecan hydrochloride, and Streptococcus agalactiae further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [1], [3]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 3 (CES3) metabolizes the drug Irinotecan hydrochloride, and Escherichia coli further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [1], [4]
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 3 (CES3) and Escherichia coli co-metabolize the drug Irinotecan hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
References
1 Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Drug Metab Dispos. 2004 May;32(5):505-11.
2 Three structurally and functionally distinct beta-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018 Nov 30;293(48):18559-18573.
3 Structure and inhibition of microbiome beta-glucuronidases essential to the alleviation of cancer drug toxicity. Chem Biol. 2015 Sep 17;22(9):1238-49.
4 Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res. 1996 Aug 15;56(16):3752-7.

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