Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0057)
DME Name Carboxylesterase 2 (CES2), Homo sapiens DME Info
UniProt ID
EST2_HUMAN
EC Number    EC: 3.1.1.1     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Bacteroidetes
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dexamethasone acetate Click to Show/Hide the Detail
                                 Drug ID DR0451   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 2 (CES2) and Bacteroides dorei co-metabolize the drug Dexamethasone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dexamethasone acetate Click to Show/Hide the Detail
                                 Drug ID DR0451   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 2 (CES2) and Bacteroides fragilis co-metabolize the drug Dexamethasone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dexamethasone acetate Click to Show/Hide the Detail
                                 Drug ID DR0451   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 2 (CES2) and Bacteroides sartorii co-metabolize the drug Dexamethasone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dexamethasone acetate Click to Show/Hide the Detail
                                 Drug ID DR0451   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 2 (CES2) and Bacteroides stercoris co-metabolize the drug Dexamethasone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Dexamethasone acetate Click to Show/Hide the Detail
                                 Drug ID DR0451   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 2 (CES2) and Bacteroides thetaiotaomicron co-metabolize the drug Dexamethasone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 2 (CES2) metabolizes the drug Irinotecan hydrochloride, and Bacteroides thetaiotaomicron further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Bacteroides uniformis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 2 (CES2) metabolizes the drug Irinotecan hydrochloride, and Bacteroides uniformis further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dexamethasone acetate Click to Show/Hide the Detail
                                 Drug ID DR0451   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 2 (CES2) and Bacteroides xylanisolvens co-metabolize the drug Dexamethasone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Clostridium perfringens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 2 (CES2) metabolizes the drug Irinotecan hydrochloride, and Clostridium perfringens further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [5]
                  Clostridium scindens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dexamethasone acetate Click to Show/Hide the Detail
                                 Drug ID DR0451   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 2 (CES2) and Clostridium scindens co-metabolize the drug Dexamethasone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Streptococcus agalactiae (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 2 (CES2) metabolizes the drug Irinotecan hydrochloride, and Streptococcus agalactiae further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [5]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 2 (CES2) metabolizes the drug Irinotecan hydrochloride, and Escherichia coli further metabolizes its metabolite (SN-38G), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [6]
                              Irinotecan hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0881   Drug Info
                                 Interaction Mechanism Human Carboxylesterase 2 (CES2) and Escherichia coli co-metabolize the drug Irinotecan hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [6]
References
1 In vitro metabolism of dexamethasone cipecilate, a novel synthetic corticosteroid, in human liver and nasal mucosa. Xenobiotica. 2011 Oct;41(10):874-84.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Drug Metab Dispos. 2004 May;32(5):505-11.
4 Three structurally and functionally distinct beta-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018 Nov 30;293(48):18559-18573.
5 Structure and inhibition of microbiome beta-glucuronidases essential to the alleviation of cancer drug toxicity. Chem Biol. 2015 Sep 17;22(9):1238-49.
6 Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res. 1996 Aug 15;56(16):3752-7.

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