Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0062)
DME Name Sulfotransferase 1A2 (SULT1A2), Homo sapiens DME Info
UniProt ID
ST1A2_HUMAN
EC Number    EC: 2.8.2.1     (Click to Show/Hide the Complete EC Tree)
Transferase
Sulfotransferase
Sulfotransferase
EC: 2.8.2.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Firmicutes
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mononitrophenol Click to Show/Hide the Detail
                                 Drug ID DR1969   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 1A2 (SULT1A2) and Bacillus megaterium co-metabolize the drug Mononitrophenol, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2], [3]
      Bacteria: Proteobacteria
                  Salmonella typhimurium (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mononitrophenol Click to Show/Hide the Detail
                                 Drug ID DR1969   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 1A2 (SULT1A2) and Salmonella typhimurium co-metabolize the drug Mononitrophenol, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4], [5]
References
1 cDNA cloning and expression of a new form of human aryl sulfotransferase. Int J Biochem Cell Biol. 1996 May;28(5):565-71.
2 Wild-type CYP102A1 as a biocatalyst: turnover of drugs usually metabolised by human liver enzymes. J Biol Inorg Chem. 2007 Mar;12(3):313-23.
3 The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.
4 Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8.
5 Prenatal diagnosis of junctional epidermolysis bullosa Herlitz type. Lancet. 1989 Oct 28;2(8670):1035-6. Letter

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