Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0067)
DME Name NADPH-dependent carbonyl reductase 1 (CBR1), Homo sapiens DME Info
UniProt ID
CBR1_HUMAN
EC Number    EC: 1.1.1.184     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.184
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Firmicutes
                  Faecalibacterium prausnitzii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Menadione Click to Show/Hide the Detail
                                 Drug ID DR1022   Drug Info
                                 Interaction Mechanism Human NADPH-dependent carbonyl reductase 1 (CBR1) and Faecalibacterium prausnitzii co-metabolize the drug Menadione, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              VUFB-11502 Click to Show/Hide the Detail
                                 Drug ID DR2704   Drug Info
                                 Interaction Mechanism Human NADPH-dependent carbonyl reductase 1 (CBR1) and Escherichia coli co-metabolize the drug VUFB-11502, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Menadione Click to Show/Hide the Detail
                                 Drug ID DR1022   Drug Info
                                 Interaction Mechanism Human NADPH-dependent carbonyl reductase 1 (CBR1) and Salmonella enterica co-metabolize the drug Menadione, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [5], [6]
References
1 Polycyclic aromatic hydrocarbon quinones and glutathione thioethers as substrates and inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase. J Biol Chem. 1987 Sep 15;262(26):12448-51.
2 Quinones are growth factors for the human gut microbiota. Microbiome. 2017 Dec 20;5(1):161.
3 The critical role of oxidative stress in the toxicity and metabolism of quinoxaline 1,4-di-N-oxides in vitro and in vivo. Drug Metab Rev. 2016 May;48(2):159-82.
4 Effects of cyadox and olaquindox on intestinal mucosal immunity and on fecal shedding of Escherichia coli in piglets. J Anim Sci. 2006 Sep;84(9):2367-73. Randomized Controlled Trial
5 Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8.
6 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.

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