General Information of Drug-Metabolizing Enzyme (DME ID: DME0073)
DME Name Alcohol dehydrogenase class-V (ADH6), Homo sapiens DME Info
UniProt ID
ADH6_HUMAN
EC Number    EC: 1.1.1.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Proteobacteria
                  Neisseria sicca (beta-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ethanol Click to Show/Hide the Detail
                                 Drug ID DR0655   Drug Info
                                 Interaction Mechanism Human Alcohol dehydrogenase class-V (ADH6) and Neisseria sicca co-metabolize the drug Ethanol, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. Alcohol Clin Exp Res. 2006 Jul;30(7):1132-42.
2 Functional profiles of coronal and dentin caries in children. J Oral Microbiol. 2018 Jul 16;10(1):1495976.

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