Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0074)
DME Name Sulfotransferase 2A1 (SULT2A1), Homo sapiens DME Info
UniProt ID
ST2A1_HUMAN
EC Number    EC: 2.8.2.14     (Click to Show/Hide the Complete EC Tree)
Transferase
Sulfotransferase
Sulfotransferase
EC: 2.8.2.14
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Enterorhabdus mucosicola (actinobacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              BIO-300 Click to Show/Hide the Detail
                                 Drug ID DR0768   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 2A1 (SULT2A1) metabolizes the drug BIO-300, and Enterorhabdus mucosicola further metabolizes its metabolite (Dihydrogenistein), which can indirectly affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Daidzein Click to Show/Hide the Detail
                                 Drug ID DR1986   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 2A1 (SULT2A1) metabolizes the drug Daidzein, and Enterorhabdus mucosicola further metabolizes its metabolite (Dihydrodaidzein), which can indirectly affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Daidzein Click to Show/Hide the Detail
                                 Drug ID DR1986   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 2A1 (SULT2A1) and Enterorhabdus mucosicola co-metabolize the drug Daidzein, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Slackia isoflavoniconvertens (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              BIO-300 Click to Show/Hide the Detail
                                 Drug ID DR0768   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 2A1 (SULT2A1) and Slackia isoflavoniconvertens co-metabolize the drug BIO-300, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                              Daidzein Click to Show/Hide the Detail
                                 Drug ID DR1986   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 2A1 (SULT2A1) and Slackia isoflavoniconvertens co-metabolize the drug Daidzein, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Streptomyces avermitilis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Daidzein Click to Show/Hide the Detail
                                 Drug ID DR1986   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 2A1 (SULT2A1) and Streptomyces avermitilis co-metabolize the drug Daidzein, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4], [5]
      Bacteria: Bacteroidetes
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              BIO-300 Click to Show/Hide the Detail
                                 Drug ID DR0768   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 2A1 (SULT2A1) metabolizes the drug BIO-300, and Bacteroides sartorii further metabolizes its metabolite (Dihydrogenistein), which can indirectly affect efficacy, safety or bioavailability of this drug. [1], [6]
                              Daidzein Click to Show/Hide the Detail
                                 Drug ID DR1986   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 2A1 (SULT2A1) and Bacteroides sartorii co-metabolize the drug Daidzein, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
                  Tannerella forsythia (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              BIO-300 Click to Show/Hide the Detail
                                 Drug ID DR0768   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 2A1 (SULT2A1) and Tannerella forsythia co-metabolize the drug BIO-300, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
                              Daidzein Click to Show/Hide the Detail
                                 Drug ID DR1986   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 2A1 (SULT2A1) and Tannerella forsythia co-metabolize the drug Daidzein, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
      Bacteria: Firmicutes
                  Eubacterium ramulus (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              BIO-300 Click to Show/Hide the Detail
                                 Drug ID DR0768   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 2A1 (SULT2A1) and Eubacterium ramulus co-metabolize the drug BIO-300, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [7]
                              Daidzein Click to Show/Hide the Detail
                                 Drug ID DR1986   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 2A1 (SULT2A1) and Eubacterium ramulus co-metabolize the drug Daidzein, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [7]
References
1 Sulfation of environmental estrogens by cytosolic human sulfotransferases. Drug Metab Pharmacokinet. 2002;17(3):221-8.
2 Conversion of daidzein and genistein by an anaerobic bacterium newly isolated from the mouse intestine. Appl Environ Microbiol. 2008 Aug;74(15):4847-52.
3 Daidzein and genistein are converted to equol and 5-hydroxy-equol by human intestinal Slackia isoflavoniconvertens in gnotobiotic rats. J Nutr. 2012 Jan;142(1):40-6.
4 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
5 Engineering of daidzein 3'-hydroxylase P450 enzyme into catalytically self-sufficient cytochrome P450. Microb Cell Fact. 2012 Jun 14;11:81.
6 Bacteroides uniformis is a putative bacterial species associated with the degradation of the isoflavone genistein in human feces. J Nutr. 2011 Jun;141(6):1120-6.
7 Anaerobic C-ring cleavage of genistein and daidzein by Eubacterium ramulus. FEMS Microbiol Lett. 2002 Mar 5;208(2):197-202.

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