Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0083)
DME Name Methylenetetrahydrofolate reductase (MTHFR), Homo sapiens DME Info
UniProt ID
MTHR_HUMAN
EC Number    EC: 1.5.1.20     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.20
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Bacteroidetes
                  Bacteroides coprophilus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Benazepril Click to Show/Hide the Detail
                                 Drug ID DR0186   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Bacteroides coprophilus co-metabolize the drug Benazepril, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Benazepril Click to Show/Hide the Detail
                                 Drug ID DR0186   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Bacteroides dorei co-metabolize the drug Benazepril, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Benazepril Click to Show/Hide the Detail
                                 Drug ID DR0186   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Bacteroides fragilis co-metabolize the drug Benazepril, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides intestinalis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Benazepril Click to Show/Hide the Detail
                                 Drug ID DR0186   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Bacteroides intestinalis co-metabolize the drug Benazepril, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Benazepril Click to Show/Hide the Detail
                                 Drug ID DR0186   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Bacteroides ovatus co-metabolize the drug Benazepril, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Benazepril Click to Show/Hide the Detail
                                 Drug ID DR0186   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Bacteroides stercoris co-metabolize the drug Benazepril, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Benazepril Click to Show/Hide the Detail
                                 Drug ID DR0186   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Bacteroides thetaiotaomicron co-metabolize the drug Benazepril, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Benazepril Click to Show/Hide the Detail
                                 Drug ID DR0186   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Bacteroides vulgatus co-metabolize the drug Benazepril, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Benazepril Click to Show/Hide the Detail
                                 Drug ID DR0186   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Bacteroides xylanisolvens co-metabolize the drug Benazepril, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Benazepril Click to Show/Hide the Detail
                                 Drug ID DR0186   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Odoribacter splanchnicus co-metabolize the drug Benazepril, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Benazepril Click to Show/Hide the Detail
                                 Drug ID DR0186   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Parabacteroides distasonis co-metabolize the drug Benazepril, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Benazepril Click to Show/Hide the Detail
                                 Drug ID DR0186   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Prevotella copri co-metabolize the drug Benazepril, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Chlamydiae
                  Chlamydia muridarum (chlamydias) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Chlamydia muridarum co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4], [5]
      Bacteria: Firmicutes
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Benazepril Click to Show/Hide the Detail
                                 Drug ID DR0186   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Blautia hansenii co-metabolize the drug Benazepril, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Blautia producta (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              ISO-901 Click to Show/Hide the Detail
                                 Drug ID DR0017   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Blautia producta co-metabolize the drug ISO-901, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [7], [8]
                  Faecalibacterium prausnitzii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Menadione Click to Show/Hide the Detail
                                 Drug ID DR1022   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Faecalibacterium prausnitzii co-metabolize the drug Menadione, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [10]
                  Lactobacillus casei (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Lactobacillus casei co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [11], [12]
                  Streptococcus sanguinis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              ISO-901 Click to Show/Hide the Detail
                                 Drug ID DR0017   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Streptococcus sanguinis co-metabolize the drug ISO-901, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [13]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Escherichia coli co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [14], [15]
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Menadione Click to Show/Hide the Detail
                                 Drug ID DR1022   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Salmonella enterica co-metabolize the drug Menadione, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [16], [17]
                  Variovorax paradoxus (beta-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Methotrexate Click to Show/Hide the Detail
                                 Drug ID DR1045   Drug Info
                                 Interaction Mechanism Human Methylenetetrahydrofolate reductase (MTHFR) and Variovorax paradoxus co-metabolize the drug Methotrexate, which can collectively affect efficacy, safety or bioavailability of this drug. [18], [19], [20]
References
1 Effects of MTHFR and MS gene polymorphisms on baseline blood pressure and Benazepril effectiveness in Chinese hypertensive patients. J Hum Hypertens. 2011 Mar;25(3):172-7.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Genetic variation: impact on folate (and choline) bioefficacy. Int J Vitam Nutr Res. 2010 Oct;80(4-5):319-29.
4 Biophysical principles predict fitness landscapes of drug resistance. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1470-8.
5 The Genital tract virulence factor pGP3 is essential for Chlamydia muridarum colonization in the gastrointestinal tract. Infect Immun. 2017 Dec 19;86(1). pii: e00429-17.
6 Methylenetetrahydrofolate reductase gene polymorphisms: genomic predictors of clinical response to fluoropyrimidine-based chemotherapy? Cancer Chemother Pharmacol. 2006 Jun;57(6):835-40.
7 Purification and characterization of NADP(+)-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Peptostreptococcus productus marburg. J Bacteriol. 1991 Feb;173(4):1414-9.
8 Characterization of NAD-dependent 3 alpha- and 3 beta-hydroxysteroid dehydrogenase and of NADP-dependent 7 beta-hydroxysteroid dehydrogenase from Peptostreptococcus productus. Biochim Biophys Acta. 1989 Aug 8;1004(2):230-8.
9 Purification and properties of 5,10-methylenetetrahydrofolate reductase, an iron-sulfur flavoprotein from Clostridium formicoaceticum. J Biol Chem. 1984 Sep 10;259(17):10845-9.
10 Quinones are growth factors for the human gut microbiota. Microbiome. 2017 Dec 20;5(1):161.
11 Molecular cloning of the gene for dihydrofolate reductase from Lactobacillus casei. Gene. 1982 Feb;17(2):229-33.
12 Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site. Biochemistry. 2008 Feb 26;47(8):2388-96.
13 Functional profiles of coronal and dentin caries in children. J Oral Microbiol. 2018 Jul 16;10(1):1495976.
14 Measurement of the uptake of radioactive para-aminobenzoic acid monitors folate biosynthesis in Escherichia coli K-12. Anal Biochem. 1994 Feb 1;216(2):427-30.
15 The influence of CsgD on the expression of genes of folate metabolism and hmp in Escherichia coli K-12. Arch Microbiol. 2013 Aug;195(8):559-69.
16 Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8.
17 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.
18 The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4.
19 The 46 kDa dimeric protein from Variovorax paradoxus shows faster methotrexate degrading activity in its nanoform compare to the native enzyme. Enzyme Microb Technol. 2016 Apr;85:38-43.
20 Isolation and molecular detection of methylotrophic bacteria occurring in the human mouth. Environ Microbiol. 2005 Aug;7(8):1227-38.

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