Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0098)
DME Name Aldo-keto reductase 1A1 (AKR1A1), Homo sapiens DME Info
UniProt ID
AK1A1_HUMAN
EC Number    EC: 1.1.1.2     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.2
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Streptomyces griseus (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1A1 (AKR1A1) and Streptomyces griseus co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1A1 (AKR1A1) and Escherichia coli co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Klebsiella pneumoniae (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1A1 (AKR1A1) and Klebsiella pneumoniae co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Neisseria sicca (beta-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ethanol Click to Show/Hide the Detail
                                 Drug ID DR0655   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1A1 (AKR1A1) and Neisseria sicca co-metabolize the drug Ethanol, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [5]
                  Raoultella planticola (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1A1 (AKR1A1) and Raoultella planticola co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
References
1 Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver. Drug Metab Dispos. 2008 Oct;36(10):2113-20.
2 Bacterial inactivation of the anticancer drug doxorubicin. Chem Biol. 2012 Oct 26;19(10):1255-64.
3 Transformation of the anticancer drug doxorubicin in the human gut microbiome. ACS Infect Dis. 2018 Jan 12;4(1):68-76.
4 Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. Alcohol Clin Exp Res. 2006 Jul;30(7):1132-42.
5 Functional profiles of coronal and dentin caries in children. J Oral Microbiol. 2018 Jul 16;10(1):1495976.

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