Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0104)
DME Name Alpha-L-iduronidase (IDUA), Homo sapiens DME Info
UniProt ID
IDUA_HUMAN
EC Number    EC: 3.2.1.76     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.76
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Fusobacteria
                  Streptobacillus moniliformis (fusobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Chondroitin sulfate Click to Show/Hide the Detail
                                 Drug ID DR0317   Drug Info
                                 Interaction Mechanism Human Alpha-L-iduronidase (IDUA) and Streptobacillus moniliformis co-metabolize the drug Chondroitin sulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2], [3]
      Bacteria: Proteobacteria
                  Desulfovibrio piger (delta-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Chondroitin sulfate Click to Show/Hide the Detail
                                 Drug ID DR0317   Drug Info
                                 Interaction Mechanism Human Alpha-L-iduronidase (IDUA) and Desulfovibrio piger co-metabolize the drug Chondroitin sulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
      Bacteria: Spirochaetes
                  Treponema vincentii (spirochetes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Chondroitin sulfate Click to Show/Hide the Detail
                                 Drug ID DR0317   Drug Info
                                 Interaction Mechanism Human Alpha-L-iduronidase (IDUA) and Treponema vincentii co-metabolize the drug Chondroitin sulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [5], [6]
References
1 MFN human ref: Chondroitin sulfate degradation.
2 A bacterial ABC transporter enables import of mammalian host glycosaminoglycans. Sci Rep. 2017 Apr 21;7(1):1069.
3 A case of Streptobacillus moniliformis infection with cutaneous leukocytoclastic vasculitis. Acta Med Okayama. 2016 Oct;70(5):377-381. Case Reports
4 Metabolic niche of a prominent sulfate-reducing human gut bacterium. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13582-7.
5 An extracellular enzyme with hyaluronidase and chondroitinase activities from some oral anaerobic spirochaetes. Microbiology. 1996 Sep;142 ( Pt 9):2567-76.
6 Identification of a Treponema denticola OppA homologue that binds host proteins present in the subgingival environment. Infect Immun. 2000 Apr;68(4):1884-92.

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