Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0114)
DME Name Prostaglandin G/H synthase 2 (COX-2), Homo sapiens DME Info
UniProt ID
PGH2_HUMAN
EC Number    EC: 1.14.99.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Oxygen paired donor oxidoreductase
EC: 1.14.99.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Mycobacterium marinum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omega-3 Fatty acids Click to Show/Hide the Detail
                                 Drug ID DR1194   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 2 (COX-2) and Mycobacterium marinum co-metabolize the drug Omega-3 Fatty acids, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Butyrivibrio fibrisolvens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Alpha-linolenic acid Click to Show/Hide the Detail
                                 Drug ID DR1988   Drug Info
                                 Interaction Mechanism Human Prostaglandin G/H synthase 2 (COX-2) and Butyrivibrio fibrisolvens co-metabolize the drug Alpha-linolenic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4], [5]
References
1 Structural basis of fatty acid substrate binding to cyclooxygenase-2. J Biol Chem. 2010 Jul 16;285(29):22152-63.
2 Selective Omega-1 oxidation of fatty acids by CYP147G1 from Mycobacterium marinum. Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):408-417.
3 Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108.
4 Immunogenic inhibition of prominent ruminal bacteria as a means to reduce lipolysis and biohydrogenation activity in vitro. Food Chem. 2017 Mar 1;218:372-377.
5 Cell-associated alpha-amylases of butyrate-producing Firmicute bacteria from the human colon. Microbiology. 2006 Nov;152(Pt 11):3281-3290.

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