Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0125)
DME Name DOPA decarboxylase (DDC), Homo sapiens DME Info
UniProt ID
DDC_HUMAN
EC Number    EC: 4.1.1.28     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.28
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Eggerthella lenta (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Levodopa Click to Show/Hide the Detail
                                 Drug ID DR0939   Drug Info
                                 Interaction Mechanism Human DOPA decarboxylase (DDC) metabolizes the drug Levodopa, and Eggerthella lenta further metabolizes its metabolite (Dopamine hydrochloride), which can indirectly affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Bacteroidetes
                  Bacteroides eggerthii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human DOPA decarboxylase (DDC) and Bacteroides eggerthii co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human DOPA decarboxylase (DDC) and Bacteroides fragilis co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human DOPA decarboxylase (DDC) and Bacteroides ovatus co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human DOPA decarboxylase (DDC) and Bacteroides thetaiotaomicron co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human DOPA decarboxylase (DDC) and Parabacteroides distasonis co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human DOPA decarboxylase (DDC) and Anaerobutyricum hallii co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Enterococcus faecalis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Levodopa Click to Show/Hide the Detail
                                 Drug ID DR0939   Drug Info
                                 Interaction Mechanism Human DOPA decarboxylase (DDC) and Enterococcus faecalis co-metabolize the drug Levodopa, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2], [5]
                  Intestinibacter bartlettii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human DOPA decarboxylase (DDC) and Intestinibacter bartlettii co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
                  Lactobacillus brevis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Levodopa Click to Show/Hide the Detail
                                 Drug ID DR0939   Drug Info
                                 Interaction Mechanism Human DOPA decarboxylase (DDC) and Lactobacillus brevis co-metabolize the drug Levodopa, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [5]
      Bacteria: Proteobacteria
                  Helicobacter pylori (epsilon-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Levodopa Click to Show/Hide the Detail
                                 Drug ID DR0939   Drug Info
                                 Interaction Mechanism Human DOPA decarboxylase (DDC) and Helicobacter pylori co-metabolize the drug Levodopa, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
References
1 Complexity of dopamine metabolism. Cell Commun Signal. 2013 May 17;11(1):34.
2 Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science. 2019 Jun 14;364(6445). pii: eaau6323.
3 Origin and metabolism of serotonin. J Cardiovasc Pharmacol. 1990;16 Suppl 3:S1-7.
4 Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein. Mol Nutr Food Res. 2013 Mar;57(3):523-35.
5 Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease. Nat Commun. 2019 Jan 18;10(1):310.
6 Drug metabolism by the host and gut microbiota: a partnership or rivalry? Drug Metab Dispos. 2015 Oct;43(10):1499-504.

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