Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0126)
DME Name L-glutamine amidohydrolase (GLS), Homo sapiens DME Info
UniProt ID
GLSK_HUMAN
EC Number    EC: 3.5.1.2     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Linear amide hydrolase
EC: 3.5.1.2
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium adolescentis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Bifidobacterium adolescentis co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium angulatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Bifidobacterium angulatum co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium dentium (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Bifidobacterium dentium co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Aquificae
                  Aquifex pyrophilus (aquificales) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Aquifex pyrophilus co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
      Bacteria: Firmicutes
                  Bacillus anthracis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Bacillus anthracis co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Bacillus pumilus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Bacillus pumilus co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Bacillus subtilis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Bacillus subtilis co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Lactobacillus brevis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Lactobacillus brevis co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4], [2]
                  Lactobacillus casei (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Lactobacillus casei co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [5]
                  Lactobacillus fermentum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Lactobacillus fermentum co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Lactobacillus johnsonii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Lactobacillus johnsonii co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
                  Lactobacillus plantarum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Lactobacillus plantarum co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Lactococcus lactis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Lactococcus lactis co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
                  Listeria monocytogenes (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Listeria monocytogenes co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
                  Streptococcus mutans (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Streptococcus mutans co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [7]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Escherichia coli co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3], [6]
                  Shigella flexneri (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Shigella flexneri co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
      Fungi: Ascomycota
                  Trichophyton interdigitale (ascomycetes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Esculin Click to Show/Hide the Detail
                                 Drug ID DR0620   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Trichophyton interdigitale co-metabolize the drug Esculin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [9]
                  Trichophyton rubrum (ascomycetes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Esculin Click to Show/Hide the Detail
                                 Drug ID DR0620   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Trichophyton rubrum co-metabolize the drug Esculin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [9], [10]
      Fungi: Basidiomycota
                  Malassezia furfur (basidiomycetes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Esculin Click to Show/Hide the Detail
                                 Drug ID DR0620   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Malassezia furfur co-metabolize the drug Esculin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [9]
                  Malassezia sympodialis (basidiomycetes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Esculin Click to Show/Hide the Detail
                                 Drug ID DR0620   Drug Info
                                 Interaction Mechanism Human L-glutamine amidohydrolase (GLS) and Malassezia sympodialis co-metabolize the drug Esculin, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [11]
References
1 Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry. 2011 Dec 20;50(50):10764-70.
2 GABA production and structure of gadB/gadC genes in Lactobacillus and Bifidobacterium strains from human microbiota. Anaerobe. 2016 Dec;42:197-204.
3 Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor design. J Mol Biol. 2007 Aug 31;371(5):1219-37.
4 Exploring the contributions of two glutamate decarboxylase isozymes in Lactobacillus brevis to acid resistance and gamma-aminobutyric acid production. Microb Cell Fact. 2018 Nov 19;17(1):180.
5 Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site. Biochemistry. 2008 Feb 26;47(8):2388-96.
6 Glutamate decarboxylase-dependent acid resistance in orally acquired bacteria: function, distribution and biomedical implications of the gadBC operon. Mol Microbiol. 2012 Nov;86(4):770-86.
7 Inactivation of glutamate racemase (MurI) eliminates virulence in Streptococcus mutans. Microbiol Res. 2016 May-Jun;186-187:1-8.
8 KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (cpd:C09264)
9 A prodrug approach to the use of coumarins as potential therapeutics for superficial mycoses. PLoS One. 2013 Nov 18;8(11):e80760.
10 Isolation of transcripts overexpressed in the human pathogen Trichophyton rubrum grown in lipid as carbon source. Can J Microbiol. 2011 Apr;57(4):333-8.
11 Physiological and molecular characterization of atypical isolates of Malassezia furfur. J Clin Microbiol. 2009 Jan;47(1):48-53.

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