| General Information of Drug-Metabolizing Enzyme (DME ID: DME0130) |
| DME Name |
Alcohol dehydrogenase class-II (ADH4), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 1.1.1.105 (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.105
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Proteobacteria |
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| Neisseria sicca (beta-proteobacteria) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| Ethanol |
Click to Show/Hide the Detail |
| Drug ID |
DR0655
Drug Info
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| Interaction Mechanism |
Human Alcohol dehydrogenase class-II (ADH4) and Neisseria sicca co-metabolize the drug Ethanol, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2] |
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| References |
| 1 |
Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75.
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| 2 |
Functional profiles of coronal and dentin caries in children. J Oral Microbiol. 2018 Jul 16;10(1):1495976.
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