Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0137)
DME Name Thymidylate synthase (TYMS), Homo sapiens DME Info
UniProt ID
TYSY_HUMAN
EC Number    EC: 2.1.1.45     (Click to Show/Hide the Complete EC Tree)
Transferase
Methylase
Methyltransferase
EC: 2.1.1.45
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Firmicutes
                  Lactobacillus casei (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Deoxy-UMP Click to Show/Hide the Detail
                                 Drug ID DR2009   Drug Info
                                 Interaction Mechanism Human Thymidylate synthase (TYMS) and Lactobacillus casei co-metabolize the drug Deoxy-UMP, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Variovorax paradoxus (beta-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Methotrexate Click to Show/Hide the Detail
                                 Drug ID DR1045   Drug Info
                                 Interaction Mechanism Human Thymidylate synthase (TYMS) and Variovorax paradoxus co-metabolize the drug Methotrexate, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4], [5]
References
1 Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine. J Biol Chem. 2002 Sep 27;277(39):36304-11.
2 Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase. Chem Biol. 1995 Sep;2(9):609-14.
3 The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4.
4 The 46 kDa dimeric protein from Variovorax paradoxus shows faster methotrexate degrading activity in its nanoform compare to the native enzyme. Enzyme Microb Technol. 2016 Apr;85:38-43.
5 Isolation and molecular detection of methylotrophic bacteria occurring in the human mouth. Environ Microbiol. 2005 Aug;7(8):1227-38.

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