Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0153)
DME Name Vitamin B12 methionine synthase (MTR), Homo sapiens DME Info
UniProt ID
METH_HUMAN
EC Number    EC: 2.1.1.13     (Click to Show/Hide the Complete EC Tree)
Transferase
Methylase
Methyltransferase
EC: 2.1.1.13
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Chlamydiae
                  Chlamydia muridarum (chlamydias) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human Vitamin B12 methionine synthase (MTR) and Chlamydia muridarum co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2], [3]
      Bacteria: Firmicutes
                  Lactobacillus casei (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human Vitamin B12 methionine synthase (MTR) and Lactobacillus casei co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4], [5]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human Vitamin B12 methionine synthase (MTR) and Escherichia coli co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6], [7]
References
1 Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab. 2007 May;91(1):85-97.
2 Biophysical principles predict fitness landscapes of drug resistance. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1470-8.
3 The Genital tract virulence factor pGP3 is essential for Chlamydia muridarum colonization in the gastrointestinal tract. Infect Immun. 2017 Dec 19;86(1). pii: e00429-17.
4 Molecular cloning of the gene for dihydrofolate reductase from Lactobacillus casei. Gene. 1982 Feb;17(2):229-33.
5 Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site. Biochemistry. 2008 Feb 26;47(8):2388-96.
6 Measurement of the uptake of radioactive para-aminobenzoic acid monitors folate biosynthesis in Escherichia coli K-12. Anal Biochem. 1994 Feb 1;216(2):427-30.
7 The influence of CsgD on the expression of genes of folate metabolism and hmp in Escherichia coli K-12. Arch Microbiol. 2013 Aug;195(8):559-69.

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