Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0170)
DME Name Serum paraoxonase/lactonase 3 (PON3), Homo sapiens DME Info
UniProt ID
PON3_HUMAN
EC Number    EC: 3.1.1.2     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.2
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium adolescentis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Bifidobacterium adolescentis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium breve (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Bifidobacterium breve co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium longum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Bifidobacterium longum co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Eggerthella lenta (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Eggerthella lenta co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Bacteroidetes
                  Bacteroides cellulosilyticus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Bacteroides cellulosilyticus co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Bacteroides dorei co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Bacteroides fragilis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides intestinalis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Bacteroides intestinalis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Bacteroides sartorii co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Bacteroides thetaiotaomicron co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Bacteroides uniformis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Bacteroides uniformis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Bacteroides vulgatus co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Bacteroides xylanisolvens co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Odoribacter splanchnicus co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Parabacteroides distasonis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides johnsonii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Parabacteroides johnsonii co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides merdae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Parabacteroides merdae co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Prevotella copri co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Clostridium botulinum co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium perfringens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Clostridium perfringens co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Enterocloster asparagiformis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Enterocloster asparagiformis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Eubacterium limosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Eubacterium limosum co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Holdemanella biformis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Holdemanella biformis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Fusobacteria
                  Fusobacterium varium (fusobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Fusobacterium varium co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
      Bacteria: Lentisphaerae
                  Victivallis vadensis (PVC bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human Serum paraoxonase/lactonase 3 (PON3) and Victivallis vadensis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 In vitro susceptibility of cultured human methanogens to lovastatin. Int J Antimicrob Agents. 2017 Feb;49(2):176-182.

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