Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0174)
DME Name Tryptophan 5-hydroxylase 2 (TPH2), Homo sapiens DME Info
UniProt ID
TPH2_HUMAN
EC Number    EC: 1.14.16.4     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Pteridine donor oxidoreductase
EC: 1.14.16.4
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Bacteroidetes
                  Bacteroides eggerthii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human Tryptophan 5-hydroxylase 2 (TPH2) and Bacteroides eggerthii co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human Tryptophan 5-hydroxylase 2 (TPH2) and Bacteroides fragilis co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human Tryptophan 5-hydroxylase 2 (TPH2) and Bacteroides ovatus co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human Tryptophan 5-hydroxylase 2 (TPH2) and Bacteroides thetaiotaomicron co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human Tryptophan 5-hydroxylase 2 (TPH2) and Parabacteroides distasonis co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human Tryptophan 5-hydroxylase 2 (TPH2) and Anaerobutyricum hallii co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Intestinibacter bartlettii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human Tryptophan 5-hydroxylase 2 (TPH2) and Intestinibacter bartlettii co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Strain differences in basal and post-citalopram extracellular 5-HT in the mouse medial prefrontal cortex and dorsal hippocampus: relation with tryptophan hydroxylase-2 activity. J Neurochem. 2007 Nov;103(3):1111-20.
2 Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein. Mol Nutr Food Res. 2013 Mar;57(3):523-35.

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