Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0176)
DME Name Tryptophanyl-tRNA synthetase mitochondrial (WARS2), Homo sapiens DME Info
UniProt ID
SYWM_HUMAN
EC Number    EC: 6.1.1.2     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-oxygen ligase
Aminoacyl tRNA synthetase
EC: 6.1.1.2
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Bacteroidetes
                  Bacteroides eggerthii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human Tryptophanyl-tRNA synthetase mitochondrial (WARS2) and Bacteroides eggerthii co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human Tryptophanyl-tRNA synthetase mitochondrial (WARS2) and Bacteroides fragilis co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human Tryptophanyl-tRNA synthetase mitochondrial (WARS2) and Bacteroides ovatus co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human Tryptophanyl-tRNA synthetase mitochondrial (WARS2) and Bacteroides thetaiotaomicron co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human Tryptophanyl-tRNA synthetase mitochondrial (WARS2) and Parabacteroides distasonis co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human Tryptophanyl-tRNA synthetase mitochondrial (WARS2) and Anaerobutyricum hallii co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Intestinibacter bartlettii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              TRP-01 Click to Show/Hide the Detail
                                 Drug ID DR0991   Drug Info
                                 Interaction Mechanism Human Tryptophanyl-tRNA synthetase mitochondrial (WARS2) and Intestinibacter bartlettii co-metabolize the drug TRP-01, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Crystal structure of tryptophanyl-tRNA synthetase complexed with adenosine-5' tetraphosphate: evidence for distributed use of catalytic binding energy in amino acid activation by class I aminoacyl-tRNA synthetases. J Mol Biol. 2007 May 25;369(1):108-28.
2 Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein. Mol Nutr Food Res. 2013 Mar;57(3):523-35.

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