Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0185)
DME Name Methionine-R-sulfoxide reductase B2 (MSRB2), Homo sapiens DME Info
UniProt ID
MSRB2_HUMAN
EC Number    EC: 1.8.4.12     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Sulfur donor oxidoreductase
Disulfide acceptor oxidoreductase
EC: 1.8.4.12
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Proteobacteria
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Methionine Click to Show/Hide the Detail
                                 Drug ID DR1043   Drug Info
                                 Interaction Mechanism Human Methionine-R-sulfoxide reductase B2 (MSRB2) and Salmonella enterica co-metabolize the drug Methionine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 The X-ray structure of the N-terminal domain of PILB from Neisseria meningitidis reveals a thioredoxin-fold. J Mol Biol. 2006 Apr 28;358(2):443-54.
2 Regulation of the methionine feedback-sensitive enzyme in mutants of Salmonella typhimurium. J Bacteriol. 1972 Jan;109(1):8-11.

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