| General Information of Drug-Metabolizing Enzyme (DME ID: DME0186) |
| DME Name |
Methionine-tRNA ligase cytoplasmic (MARS), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 6.1.1.10 (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-oxygen ligase
Aminoacyl tRNA synthetase
EC: 6.1.1.10
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Proteobacteria |
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| Salmonella enterica (enterobacteria) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| Methionine |
Click to Show/Hide the Detail |
| Drug ID |
DR1043
Drug Info
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| Interaction Mechanism |
Human Methionine-tRNA ligase cytoplasmic (MARS) and Salmonella enterica co-metabolize the drug Methionine, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2] |
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| References |
| 1 |
Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice. FASEB J. 2007 Jun;21(8):1707-13.
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| 2 |
Regulation of the methionine feedback-sensitive enzyme in mutants of Salmonella typhimurium. J Bacteriol. 1972 Jan;109(1):8-11.
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