| General Information of Drug-Metabolizing Enzyme (DME ID: DME0189) |
| DME Name |
S-adenosylmethionine synthase 1 (MAT1A), Homo sapiens
|
DME Info
|
| UniProt ID |
|
| EC Number |
EC: 2.5.1.6 (Click to Show/Hide the Complete EC Tree)
Transferase
Alkyl/aryl transferase
Alkyl/aryl transferase
EC: 2.5.1.6
|
| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
|
| Interactome |
|
| Interactions between Microbiome and DME (MICBIO)
|
| Bacteria: Proteobacteria |
|---|
| Salmonella enterica (enterobacteria) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
|
| Methionine |
Click to Show/Hide the Detail |
| Drug ID |
DR1043
Drug Info
|
| Interaction Mechanism |
Human S-adenosylmethionine synthase 1 (MAT1A) and Salmonella enterica co-metabolize the drug Methionine, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2] |
|
|
|
|
|
|
| References |
| 1 |
Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology. 2007 Jul;133(1):207-18.
|
| 2 |
Regulation of the methionine feedback-sensitive enzyme in mutants of Salmonella typhimurium. J Bacteriol. 1972 Jan;109(1):8-11.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.
