General Information of Drug-Metabolizing Enzyme (DME ID: DME0190)
DME Name S-adenosylmethionine synthase 2 (MAT2A), Homo sapiens DME Info
UniProt ID
METK2_HUMAN
EC Number    EC: 2.5.1.6     (Click to Show/Hide the Complete EC Tree)
Transferase
Alkyl/aryl transferase
Alkyl/aryl transferase
EC: 2.5.1.6
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Proteobacteria
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Methionine Click to Show/Hide the Detail
                                 Drug ID DR1043   Drug Info
                                 Interaction Mechanism Human S-adenosylmethionine synthase 2 (MAT2A) and Salmonella enterica co-metabolize the drug Methionine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology. 2007 Jul;133(1):207-18.
2 Regulation of the methionine feedback-sensitive enzyme in mutants of Salmonella typhimurium. J Bacteriol. 1972 Jan;109(1):8-11.

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