Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0198)
DME Name Aldo-keto reductase 1C4 (AKR1C4), Homo sapiens DME Info
UniProt ID
AK1C4_HUMAN
EC Number    EC: 1.1.1.357     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.357
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Bacteroidetes
                  Alistipes indistinctus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Alistipes indistinctus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides caccae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides caccae co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides cellulosilyticus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides cellulosilyticus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides coprophilus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides coprophilus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides dorei co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides eggerthii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides eggerthii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides finegoldii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides finegoldii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides fragilis co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides intestinalis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides intestinalis co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides ovatus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides sartorii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides stercoris co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides thetaiotaomicron co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides uniformis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides uniformis co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides vulgatus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Bacteroides xylanisolvens co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Odoribacter splanchnicus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides johnsonii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Parabacteroides johnsonii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides merdae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Parabacteroides merdae co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Prevotella copri co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Blautia hansenii co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Clostridium botulinum co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Holdemanella biformis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Holdemanella biformis co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Hungatella hathewayi (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Hungatella hathewayi co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Ruminococcus gnavus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Ruminococcus gnavus co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Ruminococcus torques (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Ruminococcus torques co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Norethindrone acetate Click to Show/Hide the Detail
                                 Drug ID DR1750   Drug Info
                                 Interaction Mechanism Human Aldo-keto reductase 1C4 (AKR1C4) and Escherichia coli co-metabolize the drug Norethindrone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):213-22.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

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