Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0201)
DME Name Arachidonate 5-lipoxygenase (ALOX5), Homo sapiens DME Info
UniProt ID
LOX5_HUMAN
EC Number    EC: 1.13.11.34     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen single donor oxidoreductase
Oxygen single donor oxidoreductase
EC: 1.13.11.34
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Mycobacterium marinum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Omega-3 Fatty acids Click to Show/Hide the Detail
                                 Drug ID DR1194   Drug Info
                                 Interaction Mechanism Human Arachidonate 5-lipoxygenase (ALOX5) and Mycobacterium marinum co-metabolize the drug Omega-3 Fatty acids, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Omega-3 fatty acids and inflammatory processes. Nutrients. 2010 Mar;2(3):355-74.
2 Selective Omega-1 oxidation of fatty acids by CYP147G1 from Mycobacterium marinum. Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):408-417.

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