Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0234)
DME Name Succinic semialdehyde reductase (AKR7A2), Homo sapiens DME Info
UniProt ID
ARK72_HUMAN
EC Number    EC: 1.1.1.B47     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.B47
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Streptomyces griseus (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Succinic semialdehyde reductase (AKR7A2) and Streptomyces griseus co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Succinic semialdehyde reductase (AKR7A2) and Escherichia coli co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Klebsiella pneumoniae (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Succinic semialdehyde reductase (AKR7A2) and Klebsiella pneumoniae co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Raoultella planticola (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Succinic semialdehyde reductase (AKR7A2) and Raoultella planticola co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
References
1 Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin. J Pharmacol Exp Ther. 2010 Dec;335(3):533-45.
2 Bacterial inactivation of the anticancer drug doxorubicin. Chem Biol. 2012 Oct 26;19(10):1255-64.
3 Transformation of the anticancer drug doxorubicin in the human gut microbiome. ACS Infect Dis. 2018 Jan 12;4(1):68-76.

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