| General Information of Drug-Metabolizing Enzyme (DME ID: DME0255) |
| DME Name |
Acyl-CoA thioesterase 2 (ACOT2), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 3.1.2.2 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Thioester hydrolase
EC: 3.1.2.2
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Proteobacteria |
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| Sphingomonas colocasiae (alpha-proteobacteria) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| Ibuprofen |
Click to Show/Hide the Detail |
| Drug ID |
DR0844
Drug Info
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| Interaction Mechanism |
Human Acyl-CoA thioesterase 2 (ACOT2) and Sphingomonas colocasiae co-metabolize the drug Ibuprofen, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2] |
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| References |
| 1 |
A study on the chiral inversion of mandelic acid in humans. Org Biomol Chem. 2014 Sep 14;12(34):6737-44.
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| 2 |
Genetic and chemical characterization of ibuprofen degradation by Sphingomonas Ibu-2. Microbiology. 2013 Mar;159(Pt 3):621-632.
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