Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0283)
DME Name Dimethylaniline oxidase 2 (FMO2), Homo sapiens DME Info
UniProt ID
FMO2_HUMAN
EC Number    EC: 1.14.13.8     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
NADH/NADPH donor oxidoreductase
EC: 1.14.13.8
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Firmicutes
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Propranolol hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR1367   Drug Info
                                 Interaction Mechanism Human Dimethylaniline oxidase 2 (FMO2) and Bacillus megaterium co-metabolize the drug Propranolol hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis. Microb Cell Fact. 2015 Jun 12;14:82.
2 acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.

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