Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0380)
DME Name Sulfotransferase 1B1 (SULT1B1), Homo sapiens DME Info
UniProt ID
ST1B1_HUMAN
EC Number    EC: 2.8.2.1     (Click to Show/Hide the Complete EC Tree)
Transferase
Sulfotransferase
Sulfotransferase
EC: 2.8.2.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Eggerthella lenta (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dopamine hydrochloride Click to Show/Hide the Detail
                                 Drug ID DR0532   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 1B1 (SULT1B1) and Eggerthella lenta co-metabolize the drug Dopamine hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mononitrophenol Click to Show/Hide the Detail
                                 Drug ID DR1969   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 1B1 (SULT1B1) and Bacillus megaterium co-metabolize the drug Mononitrophenol, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4], [5]
      Bacteria: Proteobacteria
                  Salmonella typhimurium (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mononitrophenol Click to Show/Hide the Detail
                                 Drug ID DR1969   Drug Info
                                 Interaction Mechanism Human Sulfotransferase 1B1 (SULT1B1) and Salmonella typhimurium co-metabolize the drug Mononitrophenol, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [6], [7]
References
1 Molecular cloning, expression, and functional characterization of novel mouse sulfotransferases. Biochem Biophys Res Commun. 1998 Jun 29;247(3):681-6.
2 Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science. 2019 Jun 14;364(6445). pii: eaau6323.
3 Comparison of 2-aminophenol and 4-nitrophenol as in vitro probe substrates for the major human hepatic sulfotransferase, SULT1A1, demonstrates improved selectivity with 2-aminophenol. Biochem Pharmacol. 2007 Jul 15;74(2):352-8.
4 Wild-type CYP102A1 as a biocatalyst: turnover of drugs usually metabolised by human liver enzymes. J Biol Inorg Chem. 2007 Mar;12(3):313-23.
5 The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.
6 Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8.
7 Prenatal diagnosis of junctional epidermolysis bullosa Herlitz type. Lancet. 1989 Oct 28;2(8670):1035-6. Letter

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