Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0417)
DME Name Galactose kinase (GALK1), Homo sapiens DME Info
UniProt ID
GALK1_HUMAN
EC Number    EC: 2.7.1.6     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.6
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              CERC-801 Click to Show/Hide the Detail
                                 Drug ID DR0759   Drug Info
                                 Interaction Mechanism Human Galactose kinase (GALK1) and Anaerobutyricum hallii co-metabolize the drug CERC-801, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium hylemonae (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              CERC-801 Click to Show/Hide the Detail
                                 Drug ID DR0759   Drug Info
                                 Interaction Mechanism Human Galactose kinase (GALK1) and Clostridium hylemonae co-metabolize the drug CERC-801, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Lactobacillus acidophilus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              CERC-801 Click to Show/Hide the Detail
                                 Drug ID DR0759   Drug Info
                                 Interaction Mechanism Human Galactose kinase (GALK1) and Lactobacillus acidophilus co-metabolize the drug CERC-801, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
                  Lactobacillus sakei (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              CERC-801 Click to Show/Hide the Detail
                                 Drug ID DR0759   Drug Info
                                 Interaction Mechanism Human Galactose kinase (GALK1) and Lactobacillus sakei co-metabolize the drug CERC-801, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [5]
References
1 Molecular and biochemical characterization of human galactokinase and its small molecule inhibitors. Chem Biol Interact. 2010 Dec 5;188(3):376-85.
2 Reclassification of Eubacterium hallii as Anaerobutyricum hallii gen. nov., comb. nov., and description of Anaerobutyricum soehngenii sp. nov., a butyrate and propionate-producing bacterium from infant faeces. Int J Syst Evol Microbiol. 2018 Dec;68(12):3741-3746.
3 Biochemical properties of L-arabinose isomerase from Clostridium hylemonae to produce D-tagatose as a functional sweetener. PLoS One. 2018 Apr 23;13(4):e0196099.
4 Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus. Int J Biol Macromol. 2016 Oct;91:338-46.
5 The acid tolerant L-arabinose isomerase from the food grade Lactobacillus sakei 23K is an attractive D-tagatose producer. Bioresour Technol. 2010 Dec;101(23):9171-7.

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