Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0419)
DME Name Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2), Homo sapiens DME Info
UniProt ID
DHI2_HUMAN
EC Number    EC: 1.1.1.B40     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.B40
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Eggerthella lenta (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Betamethasone valerate Click to Show/Hide the Detail
                                 Drug ID DR2381   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Eggerthella lenta co-metabolize the drug Betamethasone valerate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Bacteroidetes
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dexamethasone acetate Click to Show/Hide the Detail
                                 Drug ID DR0451   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Bacteroides dorei co-metabolize the drug Dexamethasone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides eggerthii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Betamethasone valerate Click to Show/Hide the Detail
                                 Drug ID DR2381   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Bacteroides eggerthii co-metabolize the drug Betamethasone valerate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Betamethasone valerate Click to Show/Hide the Detail
                                 Drug ID DR2381   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Bacteroides fragilis co-metabolize the drug Betamethasone valerate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Dexamethasone acetate Click to Show/Hide the Detail
                                 Drug ID DR0451   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Bacteroides fragilis co-metabolize the drug Dexamethasone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Betamethasone valerate Click to Show/Hide the Detail
                                 Drug ID DR2381   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Bacteroides sartorii co-metabolize the drug Betamethasone valerate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Dexamethasone acetate Click to Show/Hide the Detail
                                 Drug ID DR0451   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Bacteroides sartorii co-metabolize the drug Dexamethasone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dexamethasone acetate Click to Show/Hide the Detail
                                 Drug ID DR0451   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Bacteroides stercoris co-metabolize the drug Dexamethasone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Betamethasone valerate Click to Show/Hide the Detail
                                 Drug ID DR2381   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Bacteroides thetaiotaomicron co-metabolize the drug Betamethasone valerate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Dexamethasone acetate Click to Show/Hide the Detail
                                 Drug ID DR0451   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Bacteroides thetaiotaomicron co-metabolize the drug Dexamethasone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Betamethasone valerate Click to Show/Hide the Detail
                                 Drug ID DR2381   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Bacteroides vulgatus co-metabolize the drug Betamethasone valerate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Betamethasone valerate Click to Show/Hide the Detail
                                 Drug ID DR2381   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Bacteroides xylanisolvens co-metabolize the drug Betamethasone valerate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Dexamethasone acetate Click to Show/Hide the Detail
                                 Drug ID DR0451   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Bacteroides xylanisolvens co-metabolize the drug Dexamethasone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Betamethasone valerate Click to Show/Hide the Detail
                                 Drug ID DR2381   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Odoribacter splanchnicus co-metabolize the drug Betamethasone valerate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides johnsonii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Betamethasone valerate Click to Show/Hide the Detail
                                 Drug ID DR2381   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Parabacteroides johnsonii co-metabolize the drug Betamethasone valerate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Betamethasone valerate Click to Show/Hide the Detail
                                 Drug ID DR2381   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Blautia hansenii co-metabolize the drug Betamethasone valerate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Betamethasone valerate Click to Show/Hide the Detail
                                 Drug ID DR2381   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Clostridium botulinum co-metabolize the drug Betamethasone valerate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium scindens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Dexamethasone acetate Click to Show/Hide the Detail
                                 Drug ID DR0451   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Clostridium scindens co-metabolize the drug Dexamethasone acetate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Subdoligranulum variabile (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Betamethasone valerate Click to Show/Hide the Detail
                                 Drug ID DR2381   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Subdoligranulum variabile co-metabolize the drug Betamethasone valerate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Lentisphaerae
                  Victivallis vadensis (PVC bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Betamethasone valerate Click to Show/Hide the Detail
                                 Drug ID DR2381   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Victivallis vadensis co-metabolize the drug Betamethasone valerate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Betamethasone valerate Click to Show/Hide the Detail
                                 Drug ID DR2381   Drug Info
                                 Interaction Mechanism Human Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) and Escherichia coli co-metabolize the drug Betamethasone valerate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Metabolism of synthetic steroids by the human placenta. Placenta. 2007 Jan;28(1):39-46.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

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