Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0430)
DME Name Tyrosine-protein phosphatase STS1/TULA2 (UBASH3B), Homo sapiens DME Info
UniProt ID
UBS3B_HUMAN
EC Number    EC: 3.1.3.48     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric monoester hydrolase
EC: 3.1.3.48
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Bacteroidetes
                  Parabacteroides johnsonii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Estrone sulfate Click to Show/Hide the Detail
                                 Drug ID DR0650   Drug Info
                                 Interaction Mechanism Human Tyrosine-protein phosphatase STS1/TULA2 (UBASH3B) and Parabacteroides johnsonii co-metabolize the drug Estrone sulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Prevotella buccae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Estrone sulfate Click to Show/Hide the Detail
                                 Drug ID DR0650   Drug Info
                                 Interaction Mechanism Human Tyrosine-protein phosphatase STS1/TULA2 (UBASH3B) and Prevotella buccae co-metabolize the drug Estrone sulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3], [4]
References
1 Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism. Mol Cell Endocrinol. 2011 Jul 4;340(2):154-60.
2 Parabacteroides pacaensis sp. nov. and Parabacteroides provencensis sp. nov., two new species identified from human gut microbiota. New Microbes New Infect. 2020 Jan 7;34:100642.
3 Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints. J Clin Invest. 2017 Aug 1;127(8):2946-2956.
4 Regulating gut flora dysbiosis in obese mice by electroacupuncture. Am J Chin Med. 2018 Oct 4:1-17.

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