Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0431)
DME Name Methionine synthase reductase (MTRR), Homo sapiens DME Info
UniProt ID
MTRR_HUMAN
EC Number    EC: 1.16.1.8     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Metal ion oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.16.1.8
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Streptomyces griseus (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Methionine synthase reductase (MTRR) and Streptomyces griseus co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Chlamydiae
                  Chlamydia muridarum (chlamydias) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human Methionine synthase reductase (MTRR) and Chlamydia muridarum co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4], [5]
      Bacteria: Firmicutes
                  Faecalibacterium prausnitzii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Menadione Click to Show/Hide the Detail
                                 Drug ID DR1022   Drug Info
                                 Interaction Mechanism Human Methionine synthase reductase (MTRR) and Faecalibacterium prausnitzii co-metabolize the drug Menadione, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
                  Lactobacillus casei (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human Methionine synthase reductase (MTRR) and Lactobacillus casei co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [7], [8]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Methionine synthase reductase (MTRR) and Escherichia coli co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [9]
                              Folic acid Click to Show/Hide the Detail
                                 Drug ID DR0742   Drug Info
                                 Interaction Mechanism Human Methionine synthase reductase (MTRR) and Escherichia coli co-metabolize the drug Folic acid, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [10], [11]
                  Klebsiella pneumoniae (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Methionine synthase reductase (MTRR) and Klebsiella pneumoniae co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [9]
                  Raoultella planticola (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Methionine synthase reductase (MTRR) and Raoultella planticola co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [9]
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Menadione Click to Show/Hide the Detail
                                 Drug ID DR1022   Drug Info
                                 Interaction Mechanism Human Methionine synthase reductase (MTRR) and Salmonella enterica co-metabolize the drug Menadione, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [12], [13]
References
1 Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase. Biochemistry. 2002 Nov 12;41(45):13378-85.
2 Bacterial inactivation of the anticancer drug doxorubicin. Chem Biol. 2012 Oct 26;19(10):1255-64.
3 Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China. J Zhejiang Univ Sci B. 2008 Feb;9(2):93-9.
4 Biophysical principles predict fitness landscapes of drug resistance. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1470-8.
5 The Genital tract virulence factor pGP3 is essential for Chlamydia muridarum colonization in the gastrointestinal tract. Infect Immun. 2017 Dec 19;86(1). pii: e00429-17.
6 Quinones are growth factors for the human gut microbiota. Microbiome. 2017 Dec 20;5(1):161.
7 Molecular cloning of the gene for dihydrofolate reductase from Lactobacillus casei. Gene. 1982 Feb;17(2):229-33.
8 Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site. Biochemistry. 2008 Feb 26;47(8):2388-96.
9 Transformation of the anticancer drug doxorubicin in the human gut microbiome. ACS Infect Dis. 2018 Jan 12;4(1):68-76.
10 Measurement of the uptake of radioactive para-aminobenzoic acid monitors folate biosynthesis in Escherichia coli K-12. Anal Biochem. 1994 Feb 1;216(2):427-30.
11 The influence of CsgD on the expression of genes of folate metabolism and hmp in Escherichia coli K-12. Arch Microbiol. 2013 Aug;195(8):559-69.
12 Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8.
13 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.

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