General Information of Drug-Metabolizing Enzyme (DME ID: DME0450)
DME Name Gamma-glutamylcyclotransferase 2 (CHAC2), Homo sapiens DME Info
UniProt ID
CHAC2_HUMAN
EC Number    EC: 4.3.2.7     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-nitrogen lyase
Amidine-lyase
EC: 4.3.2.7
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Proteobacteria
                  Ralstonia solanacearum (beta-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              ANW-43980 Click to Show/Hide the Detail
                                 Drug ID DR2036   Drug Info
                                 Interaction Mechanism Human Gamma-glutamylcyclotransferase 2 (CHAC2) and Ralstonia solanacearum co-metabolize the drug ANW-43980, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2], [3]
References
1 ChaC2, an enzyme for slow turnover of cytosolic glutathione. J Biol Chem. 2017 Jan 13;292(2):638-651.
2 Characterization of the mechanism of thioredoxin-dependent activation of gamma-glutamylcyclotransferase, RipAY, from Ralstonia solanacearum. Biochem Biophys Res Commun. 2020 Mar 12;523(3):759-765.
3 Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case-control study. BJOG. 2019 Feb;126(3):349-358.

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