| General Information of Drug-Metabolizing Enzyme (DME ID: DME0450) |
| DME Name |
Gamma-glutamylcyclotransferase 2 (CHAC2), Homo sapiens
|
DME Info
|
| UniProt ID |
|
| EC Number |
EC: 4.3.2.7 (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-nitrogen lyase
Amidine-lyase
EC: 4.3.2.7
|
| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
|
| Interactome |
|
| Interactions between Microbiome and DME (MICBIO)
|
| Bacteria: Proteobacteria |
|---|
| Ralstonia solanacearum (beta-proteobacteria) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
|
| ANW-43980 |
Click to Show/Hide the Detail |
| Drug ID |
DR2036
Drug Info
|
| Interaction Mechanism |
Human Gamma-glutamylcyclotransferase 2 (CHAC2) and Ralstonia solanacearum co-metabolize the drug ANW-43980, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2], [3] |
|
|
|
|
|
|
| References |
| 1 |
ChaC2, an enzyme for slow turnover of cytosolic glutathione. J Biol Chem. 2017 Jan 13;292(2):638-651.
|
| 2 |
Characterization of the mechanism of thioredoxin-dependent activation of gamma-glutamylcyclotransferase, RipAY, from Ralstonia solanacearum. Biochem Biophys Res Commun. 2020 Mar 12;523(3):759-765.
|
| 3 |
Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case-control study. BJOG. 2019 Feb;126(3):349-358.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.
