Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0455)
DME Name Sulfurylase kinase 1 (PAPSS1), Homo sapiens DME Info
UniProt ID
PAPS1_HUMAN
EC Number    EC: 2.7.7.4     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Nucleotidyltransferase
EC: 2.7.7.4
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Proteobacteria
                  Desulfovibrio alaskensis (delta-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Sulfate Click to Show/Hide the Detail
                                 Drug ID DR2127   Drug Info
                                 Interaction Mechanism Human Sulfurylase kinase 1 (PAPSS1) and Desulfovibrio alaskensis co-metabolize the drug Sulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2], [3]
                  Desulfovibrio desulfuricans (delta-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Sulfate Click to Show/Hide the Detail
                                 Drug ID DR2127   Drug Info
                                 Interaction Mechanism Human Sulfurylase kinase 1 (PAPSS1) and Desulfovibrio desulfuricans co-metabolize the drug Sulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2], [4]
                  Desulfovibrio piger (delta-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Sulfate Click to Show/Hide the Detail
                                 Drug ID DR2127   Drug Info
                                 Interaction Mechanism Human Sulfurylase kinase 1 (PAPSS1) and Desulfovibrio piger co-metabolize the drug Sulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Desulfovibrio vulgaris (delta-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Sulfate Click to Show/Hide the Detail
                                 Drug ID DR2127   Drug Info
                                 Interaction Mechanism Human Sulfurylase kinase 1 (PAPSS1) and Desulfovibrio vulgaris co-metabolize the drug Sulfate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2], [5]
References
1 Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains. Biochemistry. 2004 Apr 13;43(14):4356-65.
2 A comparative genomic analysis of energy metabolism in sulfate reducing bacteria and archaea. Front Microbiol. 2011 Apr 19;2:69.
3 A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3171-3176.
4 Coordinated response of the Desulfovibrio desulfuricans 27774 transcriptome to nitrate, nitrite and nitric oxide. Sci Rep. 2017 Nov 24;7(1):16228.
5 Hybrid cluster proteins and flavodiiron proteins afford protection to Desulfovibrio vulgaris upon macrophage infection. J Bacteriol. 2013 Jun;195(11):2684-90.

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