Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0456)
DME Name Uridine/cytidine monophosphate kinase (UMPK), Homo sapiens DME Info
UniProt ID
KCY_HUMAN
EC Number    EC: 2.7.4.14     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.4.14
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Gemcitabine Click to Show/Hide the Detail
                                 Drug ID DR0765   Drug Info
                                 Interaction Mechanism Human Uridine/cytidine monophosphate kinase (UMPK) and Escherichia coli co-metabolize the drug Gemcitabine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Klebsiella pneumoniae (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Gemcitabine Click to Show/Hide the Detail
                                 Drug ID DR0765   Drug Info
                                 Interaction Mechanism Human Uridine/cytidine monophosphate kinase (UMPK) and Klebsiella pneumoniae co-metabolize the drug Gemcitabine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Tenericutes
                  Mycoplasma hyorhinis (mycoplasmas) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Gemcitabine Click to Show/Hide the Detail
                                 Drug ID DR0765   Drug Info
                                 Interaction Mechanism Human Uridine/cytidine monophosphate kinase (UMPK) and Mycoplasma hyorhinis co-metabolize the drug Gemcitabine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
References
1 Gemcitabine pharmacogenomics: deoxycytidine kinase and cytidylate kinase gene resequencing and functional genomics. Drug Metab Dispos. 2008 Sep;36(9):1951-9.
2 Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 Sep 15;357(6356):1156-1160.
3 Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9.

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