Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0457)
DME Name Sucrase-isomaltase intestinal (SI), Homo sapiens DME Info
UniProt ID
SUIS_HUMAN
EC Number    EC: 3.2.1.48     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.48
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              M-7403 Click to Show/Hide the Detail
                                 Drug ID DR2110   Drug Info
                                 Interaction Mechanism Human Sucrase-isomaltase intestinal (SI) and Anaerobutyricum hallii co-metabolize the drug M-7403, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Blautia obeum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              M-7403 Click to Show/Hide the Detail
                                 Drug ID DR2110   Drug Info
                                 Interaction Mechanism Human Sucrase-isomaltase intestinal (SI) and Blautia obeum co-metabolize the drug M-7403, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Coprococcus eutactus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              M-7403 Click to Show/Hide the Detail
                                 Drug ID DR2110   Drug Info
                                 Interaction Mechanism Human Sucrase-isomaltase intestinal (SI) and Coprococcus eutactus co-metabolize the drug M-7403, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
                  Eubacterium cellulosolvens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              M-7403 Click to Show/Hide the Detail
                                 Drug ID DR2110   Drug Info
                                 Interaction Mechanism Human Sucrase-isomaltase intestinal (SI) and Eubacterium cellulosolvens co-metabolize the drug M-7403, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
                  Eubacterium siraeum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              M-7403 Click to Show/Hide the Detail
                                 Drug ID DR2110   Drug Info
                                 Interaction Mechanism Human Sucrase-isomaltase intestinal (SI) and Eubacterium siraeum co-metabolize the drug M-7403, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
                  Faecalibacterium prausnitzii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              M-7403 Click to Show/Hide the Detail
                                 Drug ID DR2110   Drug Info
                                 Interaction Mechanism Human Sucrase-isomaltase intestinal (SI) and Faecalibacterium prausnitzii co-metabolize the drug M-7403, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
                  Lachnoclostridium phytofermentans (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              M-7403 Click to Show/Hide the Detail
                                 Drug ID DR2110   Drug Info
                                 Interaction Mechanism Human Sucrase-isomaltase intestinal (SI) and Lachnoclostridium phytofermentans co-metabolize the drug M-7403, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
                  Lactobacillus acidophilus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              M-7403 Click to Show/Hide the Detail
                                 Drug ID DR2110   Drug Info
                                 Interaction Mechanism Human Sucrase-isomaltase intestinal (SI) and Lactobacillus acidophilus co-metabolize the drug M-7403, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [5]
                  Ruminococcus albus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              M-7403 Click to Show/Hide the Detail
                                 Drug ID DR2110   Drug Info
                                 Interaction Mechanism Human Sucrase-isomaltase intestinal (SI) and Ruminococcus albus co-metabolize the drug M-7403, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
      Bacteria: Fusobacteria
                  Fusobacterium mortiferum (fusobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              M-7403 Click to Show/Hide the Detail
                                 Drug ID DR2110   Drug Info
                                 Interaction Mechanism Human Sucrase-isomaltase intestinal (SI) and Fusobacterium mortiferum co-metabolize the drug M-7403, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6], [7]
References
1 Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains. J Biol Chem. 2010 Jun 4;285(23):17763-70.
2 Reclassification of Eubacterium hallii as Anaerobutyricum hallii gen. nov., comb. nov., and description of Anaerobutyricum soehngenii sp. nov., a butyrate and propionate-producing bacterium from infant faeces. Int J Syst Evol Microbiol. 2018 Dec;68(12):3741-3746.
3 Novel alpha-glucosidase from human gut microbiome: substrate specificities and their switch. FASEB J. 2010 Oct;24(10):3939-49.
4 Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40.
5 Rational engineering of Lactobacillus acidophilus NCFM maltose phosphorylase into either trehalose or kojibiose dual specificity phosphorylase. Protein Eng Des Sel. 2010 Oct;23(10):781-7.
6 Sugar metabolism by fusobacteria: regulation of transport, phosphorylation, and polymer formation by Fusobacterium mortiferum ATCC 25557. Infect Immun. 1991 Dec;59(12):4547-54.
7 Clinical Fusobacterium mortiferum isolates cluster with undifferentiated Clostridium rectum species based on 16S rRNA gene phylogenetic analysis. Ann Clin Lab Sci. 2016 May;46(3):279-81.

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