Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0464)
DME Name S-methyl-5'-thioadenosine phosphorylase (MTAP), Homo sapiens DME Info
UniProt ID
MTAP_HUMAN
EC Number    EC: 2.4.2.28     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Pentosyltransferase
EC: 2.4.2.28
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Proteobacteria
                  Klebsiella pneumoniae (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              5'-Methylthioadenosine Click to Show/Hide the Detail
                                 Drug ID DR2066   Drug Info
                                 Interaction Mechanism Human S-methyl-5'-thioadenosine phosphorylase (MTAP) metabolizes the drug 5'-Methylthioadenosine, and Klebsiella pneumoniae further metabolizes its metabolite (5-methylthioribose), which can indirectly affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Methylthioadenosine Click to Show/Hide the Detail
                                 Drug ID DR2066   Drug Info
                                 Interaction Mechanism Human S-methyl-5'-thioadenosine phosphorylase (MTAP) and Klebsiella pneumoniae co-metabolize the drug Methylthioadenosine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A. Biochemistry. 2004 Jan 13;43(1):9-18.
2 Selective killing of Klebsiella pneumoniae by 5-trifluoromethylthioribose. Chemotherapeutic exploitation of the enzyme 5-methylthioribose kinase. J Biol Chem. 1990 Jan 15;265(2):831-7.

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